Clinical Features of Guillain—Barre Syndrome

Abstract

Guillain—Barre syndrome (GBS) is a disease believed to be a more frequent factor of inflammatory polyneuropathies. The pathogenesis of GBS is based on autoimmune damage to the myelin sheath of peripheral nerves. Probably, both cellular immune mechanisms and humoral ones play an important role. Most often, GBS is manifested by ascending paresis in the extremities and distal paresthesias that develop over many days. GBS is divided into the following types: more frequent — acute inflammatory demyelinating polyradiculoneuropathy (the so—called classic variant), and rarer - acute motor axonal neuropathy (more common in Japan, China and developing countries) and acute sensorimotor axonal neuropathy. A special form of GBS is Miller Fisher syndrome. In the diagnosis of GBS, the leading importance is attached to clinical evaluation, EMG results and examination of cerebrospinal fluid.