Clinical Approach to Diabetic Nephropathy

Abstract

The review presents modern information about the main mechanisms of the development and progression of diabetes. Diabetic nephropathy (DN), which is the same in both types of diabetes mellitus (DM), occurs. However, with type 2 diabetes, additional damaging factors such as obesity, dyslipidemia, hyperuricemia lead to the formation of DN and the development of end-stage renal failure.

Microalbuminuria is an early sign of DN (UIA). Active treatment of DN at the stage of MAU leads to regression and remission of laboratory signs of DN in 40-50% of patients after 2 years of treatment. Prognostic factors of DN remission are high. signal control of glycemia, control of arterial hypertension, especially when using renin blockers, the angiotensin system can lead to the reverse development of morphological changes in kidney tissues with DN. Only with maintaining normoglycemia for a long time (more than 10 years).