Prognostic Value of the Renal Vascular Resistance Index in Assessing the Progression of Chronic Kidney Disease

Abstract

Purpose of the study.To study the relationship between resistance indices (RI) of the main and intraparenchymal renal arteries, measured by Doppler ultrasound (USD), and clinical and laboratory parameters, as well as determining their prognostic significance in assessing the progression of chronic kidney disease (CKD).

Materials and methods. The study included 53 patients with CKD, divided into groups with glomerular or interstitial diseases. At the first hospitalization, the glomerular filtration rate (GFR), calculated using the CKD-EPI formula, the severity of proteinuria (PU), kidney size, thickness of the renal parenchyma and parenchymopyelic index, IR of the main and intrarenal vessels were determined. The average duration of follow-up of patients was 14±2.64 months. Upon readmission, the rate of decline in GFR was assessed.

Results. IR of the main and intrarenal vessels depends on the patient’s age and pulse pressure. In the group of patients with glomerular diseases, IR is associated with GFR and PU, while in the group of interstitial diseases - with the size and structure of the kidneys. IR of the interlobar arteries (IA) is the most sensitive predictor of deterioration in renal function with a threshold value of 0.65, comparable to the prognostic value of PU. Conclusion. IR of the main and intrarenal vessels can be considered as a prognostic factor for the deterioration of renal function.