IMPACT OF A SINGLE 5 GY IRRADIATION ON RAT IMMUNOCOMPETENT CELLS AND THE IMMUNOMODULATORY EFFECT OF LACTOPROPOLIS-AWL

Abstract

The aim of the study was to determine the effect of acute irradiation on the immune
status of experimental animals, taking into account the degree of influence of biocorrection on this
process. It was found that in white outbred male rats that received and did not receive acute irradiation,
distinctive results were obtained in the relative values of immune system cells. This was observed in the
total number of lymphocytes, cells - CD3+-, CD4+- and CD8+. A key indicator of the development of
secondary immunodeficiency is a decrease in IRI by 2.01 times in the main group. No changes were
found in CD20+ cells, in the main group of laboratory animals the number of CD16+ cells increased by
1.35 times, and in CD95+ cells it decreased by 1.51 times. The deficiency of the immune system in the
biocorrection group was relatively shallow, the biological product used had an immunostimulating
effect. It has been proven that its use reduced the negative impact of acute irradiation on the quantitative
indicators of immune system cells.