The Significance of Inflammatory Cytokins in the Early Stage of Rheumatoid Arthritis

Abstract

Today, one of the urgent problems of rheumatology remains the problem of diagnosing rheumatoid arthritis at the early stages of its development. Therefore, early diagnosis of autoimmune diseases, in particular the development of RA in patients with joint syndrome based on immunological studies, the introduction of patients at various stages of medical care in order to prevent and reduce complications, and the development of treatment methods are among the tasks that need to be addressed in medicine. Purpose: assessment of the levels of proinflammatory cytokines TNF-α and IL6 and the study of the diagnostic value of these indicators in RA and NDA. Materials and methods: 103 patients were included in the study. All the examined patients were divided into the following groups: the main group consisted of patients with RA (53 patients) and NDA (50 patients), the control group consisted of practically healthy individuals (n=20), comparable in gender and age with the group of patients with RA and NDA. Results: An analysis of the studies showed that patients with RA had an increase in TNF-α levels by 40% and IL6 by 25% compared to patients with NDA (P<0.01). In group I patients, there was a significantly higher incidence of TNF-α ≥33.9 and IL6 ≥12.8, which proves the high diagnostic accuracy and specificity of these indicators in RA and HDA. Conclusion: thus, for the early detection of RA at the NDA stage, the study of the levels of proinflammatory cytokines TNF-α and IL6 proves the high diagnostic accuracy and specificity of these indicators, which contribute to predicting the disease and reducing the incidence of complications.