Pathogenic Modification of Coinfections during Covid-19

Abstract

This article discusses the main pathogenetic mechanisms for the development of bacterial co-infection in acute respiratory infections and in coronavirus infection, in particular. Separate mechanisms were analyzed in detail, including impaired mucociliary clearance, decreased activity of local protective factors of the respiratory mucosa, and impaired antibody production. The mechanisms of dysfunction of cytokines, as well as dysfunction of receptors, are also described. Modern data on the effect of coronavirus infection on the immune system and interferon production systems are presented, which contributes to the layering of a bacterial infection.