Biochemical Parameters of Mineral Metabolism in Children With Chronic Generalized Catarrhal Gingivitis and Bronchial Asthma

Abstract

A new approach to optimizing the prevention and treatment of periodontal diseases in patients with low bone mineral density and the risk of osteopenic syndrome is the complex use of biochemical indicators of phosphorus-calcium metabolism and densitometry data.

A survey of 120 children with chronic generalized catarrhal gingivitis and bronchial asthma at the age of 7 to 12 years was carried out. All children received the necessary therapy and took glucocorticosteroids. The diagnosis of chronic generalized catarrhal gingivitis was established on the basis of basic and additional methods of investigation. The biochemical study of blood serum was carried out according to unified methods by the sets produced by the NVP «Filisit-Diagnostika».

Analyzing the content of the main biochemical parameters of blood serum in children with chronic generalized catarrhal gingivitis and bronchial asthma, we have tracked the dynamics of their content depending on the severity of bronchial asthma. The lowest content of ionized Ca was observed in the persistent form of bronchial asthma, severe course. The current reduced concentration of ionized Ca can be considered as evidence of a decrease in osteogenesis processes, a reflection of chronic disease, an imbalance in the main processes of bone remodeling. Among the examined, a significant increase in the activity of alkaline phosphatase, both in boys and girls, was diagnosed. Summarizing the obtained results, it can be concluded that the greatest diagnostic value for the prevention and treatment of periodontal diseases in patients with low bone mineral density and the risk of osteopenic syndrome is the definition of ionized calcium in the blood.

In children with chronic generalized catarrhal gingivitis, patients with bronchial asthma, there was a positive correlation between the level of ionized calcium and activity of alkaline phosphatase in serum, indicating a decrease in mineralization processes and a decreased level of bone metabolism.